Polymerized human hemoglobin facilitated modulation of tumor oxygenation is dependent on tumor oxygenation status and oxygen affinity of the hemoglobin-based oxygen carrier
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چکیده
منابع مشابه
Mixtures of tense and relaxed state polymerized human hemoglobin regulate oxygen affinity and tissue construct oxygenation
Pure tense (T) and relaxed (R) quaternary state polymerized human hemoglobins (PolyhHbs) were synthesized and their biophysical properties characterized, along with mixtures of T- and R-state PolyhHbs. It was observed that the oxygen affinity of PolyhHb mixtures varied linearly with T-state mole fraction. Computational analysis of PolyhHb facilitated oxygenation of a single fiber in a hepatic h...
متن کاملImpact of hemoglobin concentration and affinity for oxygen on tissue oxygenation: the case of hemoglobin-based oxygen carriers.
In patients undergoing exchange-transfusion with hemoglobin (Hb)-based oxygen (O₂) carriers (HBOC), native Hb coexists with newly transfused Hb. The two Hb types share the same arterial and venous PO₂, but their affinities for O₂ vary. A simple spreadsheet model is described aiming at evaluating the contribution of each Hb type to the overall O₂ transport characteristics as a function of the ba...
متن کاملTissue oxygenation and muscular substrate turnover in two subjects with high hemoglobin oxygen affinity.
Oxygen transport to and substrate turnover in leg muscle were studied at rest and during light and heavy upright bicycle exercise in two brothers with a hereditary hemoglobinopathy associated with high oxygen affinity (P50 = 13 mmHg). Femoral venous oxygen tension was below normal and femoral venous oxygen saturation above normal at rest and during exercise. Thus, the arterial-femoral venous ox...
متن کاملOxygen Affinity of Hemoglobin and Red Cell Acid Base Status
This volume is the publication of the proceedings of the symposium held in May of 1971. Most of the chapters are relatively brief contributions, often by major authorities. The topics discussed include the interaction between hemoglobin and oxygen, carbon dioxide, the red cell membrane, carbonic anhydrase, the regulation of intermediary metabolism of the red cell and of the oxygen affinity of h...
متن کاملImpact of Oxygenation Status on the Noninvasive Measurement of Hemoglobin.
BACKGROUND Noninvasive monitoring of hemoglobin (SpHgb) via pulse oximetry has the potential to alert caregivers to blood loss. Previous studies have demonstrated that changes in oxygenation may impact accuracy. METHODS Twenty normal volunteers were monitored using SpHgb at sea level, during ascent to 14,000 feet, at 14,000 feet with 100% oxygen delivery, and again at sea level. Each period c...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-68190-0